Krueppel-like factor 15 regulates Wnt/b- catenin transcription and controls cardiac progenitor cell fate in the postnatal heart

نویسندگان

  • Claudia Noack
  • Maria-Patapia Zafiriou
  • Hans-Joerg Schaeffer
  • Anke Renger
  • Elena Pavlova
  • Rainer Dietz
  • Wolfram H. Zimmermann
  • Martin W. Bergmann
  • Laura C. Zelarayán
چکیده

(1) Heart Research Center Göttingen (HRCG), Univer Göttingen, Georg-August-University Göttingen, Germ (2) Max-Delbrück-Center for Molecular Medicine, Berli (3) Max Planck Institute of Biochemistry, Martinsried, (4) Department of Cardiology, Asklepios Klinik St. Georg *Corresponding author: Tel: þ49 551 395879; Fax: þ E-mail: [email protected] **Corresponding author: Tel: þ49 4

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Krueppel-like factor 15 regulates Wnt/β-catenin transcription and controls cardiac progenitor cell fate in the postnatal heart

Wnt/β-catenin signalling controls adult heart remodelling in part via regulation of cardiac progenitor cell (CPC) differentiation. An enhanced understanding of mechanisms controlling CPC biology might facilitate the development of new therapeutic strategies in heart failure. We identified and characterized a novel cardiac interaction between Krueppel-like factor 15 and components of the Wnt/β-c...

متن کامل

S13-03 HOX transcription factor regulation of adult stem/progenitor cell behavior in response to injury

The purification, renewal and differentiation of native cardiac progenitors would form a mechanistic underpinning for unraveling steps for cardiac cell lineage formation, and their links to forms of congenital and adult cardiac diseases. Previously, we have reported the identification of isl1+ cardiac progenitors in postnatal rat, mouse and human myocardium (1). The discovery of native cardiobl...

متن کامل

The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.

Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. Transcription factor 7-like 2 (TCF7l2), also known as TCF4, is a Wnt effector induced transiently in the oligodendroglial lineage. A well accepted dogma is that TCF7l2 inhibits oligodendrocyte differentiation through activation of Wnt/β-catenin signaling. We report that TCF7l2 is...

متن کامل

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure.

BACKGROUND How canonical Wnt/β-catenin signals in adult hearts, especially in different diseased states, remains unclear. The proto-oncogene, c-Myc, is a Wnt target and an early response gene during cardiac stress. It is not clear whether c-Myc is activated or how it is regulated during heart failure. METHODS AND RESULTS We investigated canonical Wnt/β-catenin signaling and how it regulated c...

متن کامل

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.

Progenitor cells of the first and second heart fields depend on cardiac-specific transcription factors for their differentiation. Using conditional mutagenesis of mouse embryos, we define the hierarchy of signaling events that controls the expression of cardiac-specific transcription factors during differentiation of cardiac progenitors at embryonic day 9.0. Wnt/β-catenin and Bmp act downstream...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012